Contact Us

Please Specify Referral Source*

or

May we leave voice messages pertaining to your condition and our treatment at the number you've provided on this form?*

 Yes No

May we email you information pertaining to your condition and our treatment at the email address you've provided on this form?*
 Yes No

Innovative PPD (Postpartum depression) treatment

Innovative PPD (Postpartum depression) treatment

What is PPD (Postpartum depression) ?

Postpartum depression (PPD) is a major form of depression and is less common than postpartum blues. PPD includes all the symptoms of depression but occurs only following childbirth. It can begin any time after delivery and can last up to a year. PPD is estimated to occur in approximately 10 to 20 percent of new mothers.

What are the symptoms of PPD?

innovative-postpartum-depression-PPD-treatment-ketamine-300x225 Innovative PPD (Postpartum depression) treatment Los Angeles Southern CaliforniaSymptoms of postpartum depression (PPD) are not the same for every woman.

Sadness is only one symptom of PPD. Some women may be more aware of an increase in anxiety and irritability. Only your healthcare provider can determine if you have PPD.

If you experience any of the following symptoms, tell your doctor right away:

  • Feeling sad, hopeless, empty, or overwhelmed
  • Crying more often than usual
  • Worrying or feeling overly anxious
  • Feeling moody, irritable, or restless
  • Oversleeping or being unable to sleep when your baby is asleep
  • Having trouble concentrating and making decisions
  • Frequent feelings of anger or rage
  • Losing interest in activities that are usually enjoyable
  • Suffering from physical aches and pains
  • Eating too little or too much
  • Avoiding friends and family
  • Having trouble bonding with your baby
  • Persistently doubting your ability to care for your baby
  • Thinking about harming yourself or your baby

Postpartum psychosis

With postpartum psychosis — a rare condition that typically develops within the first week after delivery — the signs and symptoms are severe. Signs and symptoms may include:

  • Confusion and disorientation
  • Obsessive thoughts about your baby
  • Hallucinations and delusions
  • Sleep disturbances
  • Excessive energy and agitation
  • Paranoia
  • Attempts to harm yourself or your baby

Postpartum psychosis may lead to life-threatening thoughts or behaviors and requires immediate treatment.

PPD Causes & Risk Factors

Causes

There’s no single cause of postpartum depression, but physical and emotional issues may play a role.

Physical changes. After childbirth, a dramatic drop in hormones (estrogen and progesterone) in your body may contribute to postpartum depression. Other hormones produced by your thyroid gland also may drop sharply — which can leave you feeling tired, sluggish and depressed.

Emotional issues. When you’re sleep deprived and overwhelmed, you may have trouble handling even minor problems. You may be anxious about your ability to care for a newborn. You may feel less attractive, struggle with your sense of identity or feel that you’ve lost control over your life. Any of these issues can contribute to postpartum depression.

Risk factors

Any new mom can experience postpartum depression and it can develop after the birth of any child, not just the first. However, your risk increases if:

  • You have a history of depression, either during pregnancy or at other times
  • You have bipolar disorder
  • You had postpartum depression after a previous pregnancy
  • You have family members who’ve had depression or other mood disorders
  • You’ve experienced stressful events during the past year, such as pregnancy complications, illness or job loss
  • Your baby has health problems or other special needs
  • You have twins, triplets or other multiple births
  • You have difficulty breast-feeding
  • You’re having problems in your relationship with your spouse or significant other
  • You have a weak support system
  • You have financial problems
  • The pregnancy was unplanned or unwanted

Treatment

Treatment and recovery time vary, depending on the severity of your depression and your individual needs. If you have an underactive thyroid or an underlying illness, your doctor may treat those conditions or refer you to the appropriate specialist. Your doctor may also refer you to a mental health professional.

Innovative PPD (Postpartum depression) Treatment with Ketamine

A traditional course of treatment for mothers diagnosed with postpartum depression is antidepressant medications. The biggest limitation of antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRIs) is that the drug can enter the breast milk when breastfeeding. Furthermore, it can take one to two months for the medications to take full effect and may result in various unpleasant side effects.

Looking at these drawbacks, physicians are increasingly turning to Ketamine Infusion Therapy as a promising alternative to conventional treatments for postpartum depression. Ketamine Therapy has proven to have a high success rate treating mood disorders and it is fast-acting with little to no risk to the child. The symptoms of postpartum depression can be eliminated within a matter of days instead of weeks.

Furthermore, the mother does not have to become dependent on a drug to maintain a stable mood. In many cases, the patient may only require as few as six infusions of Ketamine Therapy to achieve sustainable relief for several months. That provides her with plenty of time to develop a healthy bond with the newborn and reassess her long-term treatment options, if required.

In many cases, while Ketamine Infusion Therapy works to address the postpartum depression symptoms, the mother’s hormones and other PPD contributing factors would have stabilized. Therefore, they would not require any further treatment.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Ketamine Infusion Therapy: an Innovative and Effective Treatment for Suicidal Ideation

Ketamine Treatments

Ketamine-300x200 Ketamine Infusion Therapy: an Innovative and Effective Treatment for Suicidal Ideation Los Angeles Southern CaliforniaDeath by suicide is a serious and rising concern in the United States today. While suicide has not gotten as much “press” as opioid overdoses, for example, or violent homicide, suicide is the 10th leading cause of death in the United States, with approximately 45,000 people dying from suicide each year. Statistically, that’s twice as many suicides as homicides, and equates to about 113 suicides each day, or 1 every 13 minutes. [1] Moreover, the statistics clearly show that some groups are at significantly higher risk: suicide is the second leading cause of death for young people between the ages of 10 and 34, while according to the VA, veterans have a suicide rate 50% higher than the rest of the population.[2] Clearly, as these statistics demonstrate, we need to take serious and real steps to improve our ability to recognize individuals at risk of suicide and offer them timely and effective assistance.

According to the same CDC data, each year more than 9 million adults in the United States confess that they have experienced suicidal ideation, again with a higher percentage among adults 18 to 25. Suicidal ideation is defined as thinking about and/or planning suicide, ranging from only a brief or fleeting thought to developing a detailed plan for suicide. Of course, most people who experience suicidal ideation do not act on these thoughts, yet clearly the medical community is—as it should be—focused on developing a variety of methods of providing effective and fast-acting relief from suicidal ideation before suicidal thoughts can develop into suicidal action.

With the FDA’s quite recent approval of a ketamine-derivative called esketamine (marketed as SPRAVATO™) as a fast-acting and effective treatment for depression, attention is once again focused on the potential of ketamine as an innovative treatment option for other mood disorders. The key lies in the words “fast acting”. When administered directly into the blood stream through an IV—a treatment known as Ketamine Infusion Therapy—ketamine appears to deliver, for many patients, a rapid improvement in mood and decrease in suicidal ideation. Thus, by reducing suicidal ideation quickly, the ketamine treatments may, in effect, “buy time” for other interventions to succeed.

Why is this treatment innovative? Traditionally (or at least since the late 1980s), the medical community has relied on a class of drugs known as antidepressants, such as Prozac, Zoloft, or Wellbutrin, for instance, to relieve depressive symptoms, anxiety, PTSD, and other mood disorders believed (in most cases) to underlie suicidal ideation. Unfortunately, antidepressants take a long time to “take effect”, up to several weeks, in most cases. Moreover, many patients must try different types of antidepressants to find one that offers relief with fewer side effects, while for a large number of patients, antidepressants actually do not work at all. Yet a patient who may be actively contemplating suicide doesn’t have the time to wait, experiment, and see what works. He or she needs something that works right away. Intervention with Ketamine Infusion Therapy may be able to eliminate the “risk period” before these traditional treatments “kick in”.

Two Recent Studies Demonstrate Ketamine’s Potential as a Treatment Option for Suicidal Ideation

Ketamine as an innovative treatment option for suicidal ideation is supported by two recently-published studies.

The first study, published online in late 2017 in the Journal of American Psychiatry, compared patient responses to two different treatment approaches: one group received low dose ketamine infusions while a second group received a low dose of a sedative called midazolam.[3] Conducted by researchers at Columbia University Medical Center, the study included 80 adults with major depressive symptoms and suicidal ideation. While both groups responded positively to treatment within 24 hours, the group that received ketamine saw a statistically greater reduction in suicidal ideation than the group that received midazolam. Specifically, 55% of the ketamine group was assessed at experiencing a 50% or greater reduction in suicidal ideation, while only 30% of the midazolam group experienced a similar reduction. Moreover, researchers noted that the impact of the ketamine infusion treatments lasted for up to six weeks after the study began.

The second, published in 2018 in the Journal of Affective Disorders, looked at data from five clinical trials involving ketamine infusions as treatment for treatment-resistant major depressive disorder or bipolar depression. [4] As suicidal ideation was one of the evaluation markers, the researchers in this compilation study were able to determine that nearly all of the individuals in the study experienced some decline in suicidal ideation after ketamine infusions. The study divided the patients into 3 distinct subgroups: remitters, responders, and nonresponders. After day 1 of treatment, 71% of remitters, 39% of responders, and 12% of nonresponders showed a significant decline in suicidal ideation, while by day 2, remitters actually had zero suicidal ideation. Thus, the researchers concluded that for many, although not

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

 

[1] https://www.cdc.gov/violenceprevention/pdf/suicide-datasheet-a.pdf

[2] https://www.mentalhealth.va.gov/docs/data-sheets/OMHSP_National_Suicide_Data_Report_2005-2016_508.pdf

[3] Michael F. Grunebaum, et al. Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical TrialAmerican Journal of Psychiatry, 2018; 175:4; pages 327-335. Published Online: 5 Dec 2017. https://doi.org/10.1176/appi.ajp.2017.17060647

[4] Ballard ED, Yarrington JS, Farmer CA, et al. Characterizing the course of suicidal ideation response to ketamineJ Affect Disord. 2018; 241:86-93. doi: 10.1016/j.jad.2018.07.077.

What is SPRAVATO (esketamine)?

SPRAVATO – FDA Approves Esketamine Nasal Spray For Hard-To-Treat Depression

SPRAVATO-FDA-Approves-Esketamine-Nasal-Spray-For-Hard-To-Treat-Depression-1024x896 What is SPRAVATO (esketamine)? Los Angeles Southern California

According to the National Institute of Mental Health, depression is one of the most common mental health disorders among adults in the United States today, and a leading cause of both prescription drug usage and disability claims. An estimated 17 million adults have at least one significant depressive episode every year, over 7% of the population of the United States. The percentage increases to over 13% when the age range narrows to adults aged 18-25. (Source: https://www.nimh.nih.gov/health/statistics/major-depression.shtml)

For nearly three decades (since the late 1980s), individuals with significant depressive symptoms or clinical depression have been treated with a class of prescription drugs commonly called “antidepressants”. In fact, there are a number of different types of antidepressants such as SSRIs (Prozac and Zoloft), SNRIs (Cymbalta and Effexor XR), MAOIs (Nardil and Marplan), and others such as Wellbutrin and Tofranil, to name just a few. Yet while the wide range of different types and formulations of antidepressants enable some patients to find one that works for them, antidepressants have significant limitations for many patients, including the length of time it takes for antidepressants to “kick in” as well as a long list of negative side effects. Most problematic, however, is that for many patients, antidepressants simply don’t work.

SPRAVATO™ Ketamine offers new hope to patients who have not found relief from depression from traditional antidepressants. The first ketamine-based treatment for depression to be approved by the FDA, SPRAVATO™ is a nasal spray composed of esketamine, a derivative of ketamine, a well-known, powerful, and highly effective anesthetic. It is designed for patients with treatment-resistant depression, in other words, for patients who have tried two or more different antidepressants (in appropriate dosages and durations) without positive results.

I suffer from clinical depression. Should I try SPRAVATO™?       

If you suffer from a major depressive disorder and have tried at least two different types of traditional antidepressants without relief from depressive symptoms, SPRAVATO™ may offer a more effective treatment option. Spravato is an option for patients, however, the success rates are not as high as Ketamine Infusion Therapy since it’s a nasal spray. This nasel treatment is designed to be administered two times per week for a period of four weeks, then one time per week for an additional four weeks. If effective, SPRAVATO™ can then be taken once a week or once every two weeks, depending on effectiveness. According to manufacturer specifications, it should be taken along with a daily oral antidepressant.

Clinical studies involving SPRAVATO™ are now showing what many physicians and psychiatrists have believed for quite some time: that low dose ketamine, or esketamine in the SPRAVATO™ formulation, offers fast-acting and highly effective relief from depressive symptoms. At four weeks, patients utilizing STRAVATO™ demonstrated fewer depressive symptoms than those patients who utilized a placebo (both in conjunction with the use of a daily oral antidepressant). Moreover, while SPRAVATO™ does carry a risk of side effects, like all medications, those side effects were—generally speaking—less severe and disruptive than some potential side effects of antidepressants. In order to continue managing known and potential side effects of SPRAVATO™, all patients seeking to start treatment will be enrolled in a Risk Evaluation and Mitigation Study (REMS), required by the FDA.

While the nasal spray is self-administered, it must be administered while in the clinic and while under the close supervision of a healthcare professional. Once you administer the spray, a healthcare professional will monitor you closely for two hours to watch for any negative side effects. It is important to note that you will need to plan transportation to and from each SPRAVATO™ treatment, as you cannot drive or operate machinery until the next day. During your initial consultation, your healthcare professional will help you understand what to expect during a typical treatment session and how to prepare; it’s important at this time to inform your provider about all medications—including any over-the-counter medications—that you are currently taking.

If you are suffering from depression and are among the 30% of individuals who have not found relief from traditional antidepressants, ketamine-based treatment options may be the right solution for you. We encourage you to contact us for more information.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

FDA Approves SPRAVATO™: What’s Next for Ketamine Therapy?

Ketamine is FDA approved to treat depression – Now what?

Ketamine-Drug-History-300x200 FDA Approves SPRAVATO™: What’s Next for Ketamine Therapy? Los Angeles Southern CaliforniaThis past March, the FDA took a huge step forward in the fight against depression by approving a new drug called SPRAVATO™, literally the first time in decades that the FDA has approved a medication for depression that works in a radically different way than traditional antidepressants. Why is SPRAVATO™ different than other depression medications? SPRAVATO™ is different from antidepressants because it is formulated from the same chemical compound as ketamine, an effective and well-known anesthetic the medical benefits of which have, unfortunately, been tainted by ketamine’s reputation as a party drug.

Does this mean that ketamine been approved by the FDA for the treatment of depression? The straight answer is…“sort of”. Healthcare professionals have been successfully utilizing Ketamine Infusion Therapy, delivered in low doses directly into the blood stream via IV, for a decade or more in the treatment of mood disorders such as depression and anxiety. Because ketamine is approved by the FDA as an anesthetic, this use is perfectly legal but considered “off-label”.

By approving SPRAVATO™, the FDA has approved the use of a ketamine derivative, esketamine, for the treatment of depression. Chemically speaking, esketamine is one-half of the ketamine molecule. By isolating and patenting esketamine, the makers of SPRAVATO™—Janssen Pharmaceutical—have effectively figured out how to monetize a chemical compound that was already FDA approved, widely-used, and not covered by a patent.

How is SPRAVATO™ different than IV Ketamine Therapy?

Healthcare specialists focusing on the treatment of depression and other mental health disorders are applauding the FDA’s long-overdue approval of a ketamine-based treatment option. SPRAVATO™ has a number of benefits. Because it is a self-administered nasal spray (although only in a clinical setting under close supervision), some patients may find it easier to use and more comfortable than Ketamine Therapy, which is administered by a healthcare professional through an IV directly into the bloodstream. Additionally, because SPRAVATO™ is an FDA-approved drug, health insurance may help defray some of the cost of the treatment.

However, experts caution that there are differences between SPRAVATO™ and Ketamine Therapy. Most importantly, SPRAVATO™ may not be as effective. As a nasal spray, it is difficult to vary the dosage or to verify how much of the drug reaches the bloodstream; for example, some of the spray may drift uselessly down the throat. Ketamine Therapy, on the other hand, involves a administering a low dose of ketamine (not esketamine) through an IV. This means that the dosage can be carefully controlled, with the entire dosage going directly into the body. Moreover, the dosage can be altered if necessary during treatment to maximize effectiveness while minimizing potential side effects.

Cost may also be a factor as well. SPRAVATO™ is likely to be more expensive than Ketamine Therapy. Ketamine is, as noted above, widely available, not covered by a patent, and relatively inexpensive. The cost of Ketamine Infusion Therapy stems primarily from the cost of administering the drug: maintaining the clinic and covering the time of the healthcare professionals who administer the drug and monitor the patient before, during, and after treatment. SPRAVATO™, on the other hand, is itself extremely expensive because Janssen discovered a way to create a patent-able drug, in addition to the cost of the clinic and healthcare professionals. Thus, even if insurance covers some of the treatment, it may still prove more costly than Ketamine Therapy.

What’s next for ketamine?

Despite the continued benefits of Ketamine Therapy over SPRAVATO™, most healthcare professionals are excited by the FDA approval and many clinics that specialize in Ketamine Infusion Therapy either already are or plan to become certified SPRAVATO™ providers. The fact is that in either formulation, ketamine and esketamine both have the potential to deliver powerful and highly effective relief to patients suffering from treatment-resistant depression. At the very least, FDA approval of SPRAVATO™ legitimizes ketamine as an effective treatment option and in the best case scenario, this is simply the first step in making this powerful treatment widely available to the millions of Americans who may benefit from it.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Can Ketamine Help the Pain in Adults and Children with Cancer?

Coping with Cancer-related Pain

Can-Ketamine-Help-the-Pain-in-Adults-and-Children-with-Cancer-300x200 Can Ketamine Help the Pain in Adults and Children with Cancer? Los Angeles Southern CaliforniaAccording to the American Cancer Society, more than 1.5 million people—both adults and children—will be diagnosed with cancer this year. The good news is that thanks to advances in early detection (for adults) and treatment options (and reductions in cancer-causing habits such as smoking), deaths from cancer have decreased 27% over the past 25 years. Yet even with all of our amazing medical and scientific advances, for the millions of Americans with this dreaded disease, the fight against cancer is exhausting, difficult, and for many patients, quite often very painful.

Generally speaking, about half of all patients diagnosed with cancer will experience some type of cancer-related pain before, during, and even after treatment. The pain might be temporary or chronic, widespread throughout the body or focused in a single area, mild or severe. In some cases, the pain may be related to the cancer itself; a tumor, for instance, may grow large enough to cause pain by pressing on nerves, bones, and/or organs. For many patients, treatment for cancer itself, whether surgery, radiation, chemotherapy or a combination thereof, can be exceedingly painful.

Treating pain in cancer patients requires a tailored approach unique to each individual. The specific approach will depend heavily on the type of pain they are experiencing and the type of cancer they are fighting, as well as the patient’s general health. In some cases, a surgical procedure may be able to remove or minimize the source of the pain. For others, medications may be appropriate; depending on the severity of the pain, and prescription strength; non-opioids such as acetaminophen or ibuprofen may be sufficient, while other patients may require the careful use of opioids such as oxycodone or morphine.

Refractory Pain in Cancer Patients and Ketamine Infusion Therapy

Unfortunately, some cancer patients will experience what physicians refer to as refractory pain. Pain is considered refractory when it proves resistant to traditional non-opioid and/or opioid treatment options. For these patients, the well-known anesthetic ketamine may provide an alternative, and more effective, treatment option. Ketamine has been used for decades as a fast-acting field anesthetic by the military and in human and veterinary medicine, and continues to be used on both adults and children during short but painful surgical procedures. When delivered in sub-anesthetic dosages through a slow and carefully-controlled IV infusion, ketamine has shown to offer highly effective pain relief. Moreover, it does so without the long-term risk of addiction presented by opioid pain medications.

How Ketamine Works to Deliver Effective Relief from Cancer Pain

Researchers currently believe that ketamine may present a more effective treatment option for cancer-related refractory pain because it acts differently on the brain than opioid-based medications. Currently, researchers theorize that ketamine resets the central nervous system’s sensitization to pain. In other words, the infusion of low dosages of ketamine works by calming the nerves themselves, thus increasing the threshold at which neurons in the body begin sending pain signals up to the brain. An increased threshold for pain signals therefore reduces the amount of pain signals sent to the brain, leading to an overall reduction in the amount of pain the patient perceives.

Ketamine Infusion Therapy as a treatment option for patients coping with refractory cancer pain usually involves a regular series of low dose ketamine infusions. If necessary, the initial series may be followed up by maintenance infusions at longer intervals to provide longer-term pain relief. The ketamine treatments involve the slow administration of an extremely low dose of ketamine directly into the bloodstream through an IV. At Ketamine Clinics of Los Angeles, a state-of-the-art clinic accredited by AAAASF, Dr. Steven L. Mandel specializes in the use of digital infusion pumps that deliver precisely tailored dosages that can be altered very quickly as needed to match each patient’s response to the treatment.

Each Ketamine Infusion Treatment plan and individual infusion is uniquely tailored to meet the needs of every patient. Most importantly, we work closely with the patient’s entire medical team to ensure that the Ketamine Infusion Therapy augments and supplements—but does not interfere with—the cancer treatment itself. In this way, we believe that Ketamine Infusion Therapy can play a critical role in helping both adult and pediatric cancer patients win their battle against cancer.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Ketamine may help to relieve osteoarthritis pain and inflammation

Alternative Inflammation, Pain and Arthritis Treatment

shutterstock_114105163-300x300 Ketamine may help to relieve osteoarthritis pain and inflammation Los Angeles Southern CaliforniaPainful inflammation can impact anyone, at any time. In many cases, the inflammation—though painful—is a temporary condition caused by an acute injury (like a twisted ankle or knee), an infection, or even just a basic wound. In these cases, treatment is usually pretty simple and straightforward. If the inflammation is caused by a wound or infection, the key is rapid treatment with antibiotics. If the source of the inflammation is an acute injury, physicians usually recommend the so-called RICE treatment: Rest, Ice, Compression, and Elevation. In all cases of this temporary, and usually fairly mild, inflammatory pain, treatment may also involve anti-inflammatory medications known as an NSAIDs (Non-Steroidal Anti Inflammatory Drugs).

Chronic inflammation of the joints is known generally as “arthritis”, and unfortunately, it’s far more common than most people realize. “Arthritis”—a generic term encompassing more than 100 different types of inflammatory joint pain and/or joint disease—affects more than 50 million adults and 300,000 children. Because of the extremely painful and debilitating nature of many forms of arthritis, it is the leading cause of disability in the United States today. The most common symptoms of arthritis include swelling, stiffness, decreased range of motion, and of course pain. Severe arthritis often leads to significant and chronic pain, and over time can lead to permanent changes and damage to the affected joints.

As noted above, there are over 100 different types of inflammatory conditions that fall within the umbrella of arthritis. However, the two most common types are:

  • Degenerative arthritis: Osteoarthritis (OA) is the most prevalent form of arthritis, especially among older Americans, potentially affecting 30% of men and almost 35% of women aged 65 and older. OA causes the cartilage cushioning the ends of the bones to wear away until the bones in the affected joint rub against each other.
  • Inflammatory arthritis: Inflammatory arthritis is what is known as an autoimmune disease, when the body’s immune system goes into overdrive and mistakenly begins to attack itself. In the case of inflammatory arthritis, the body’s immune system attacks the joints, causing uncontrolled inflammation. The two most common types of inflammatory arthritis are Rheumatoid arthritis (RA) and Psoriatic arthritis.

The key to managing and treating both degenerative arthritis and inflammatory arthritis is both early diagnosis and aggressive treatment. For OA, this often means balancing periods of rest while still staying active and physically fit and controlling the inflammation and pain with hot and cold therapies and OTC anti-inflammatories; in severe cases, joint replacement may be required. For RA and other types of inflammatory arthritis, the key is slowing the progression of the disease to minimize pain and hopefully prevent permanent joint damage with anti-rheumatic drugs.

Another potential tool in the fight against inflammatory pain—whether caused by OA, RA, or another type of inflammation—may be Ketamine Infusion Therapy. New research is beginning to demonstrate that ketamine may assist in the fight against inflammatory pain in two distinct yet overlapping ways:

Ketamine offers relief from chronic, severe pain stemming from arthritis and inflammation

Scientists currently believe that low dose ketamine infusions help fight chronic pain from inflammation, arthritis, migraines, Complex Regional Pain Syndrome, and cancer by altering the central nervous system’s sensitization to pain. By acting as a calming agent on the nerves of the central nervous system, ketamine raises the threshold at which the neurons start sending pain signals to the brain. With a higher threshold for pain signaling, fewer pain signals are sent to the brain, thereby reducing the experience of pain for the patient.

Ketamine may act as an anti-inflammatory

We are continually learning more about the bodily processes at the root of chronic conditions such as inflammation. Recent studies indicate that elevated levels of certain chemicals such as glutamate may have a “pro-inflammatory” affect: when glutamate interacts with NMDA receptors, it initiates a cascade of signals in the body that can spark arthritic inflammation. Ketamine is an NMDA receptor antagonist, meaning that it blocks the ability of glutamate to spark a pro-inflammatory signal, thereby potentially reducing inflammation at the source, deep within the body’s own complex chemical reactions.

Ketamine has been available as a safe and fast-acting anesthetic for many, many years now. Yet researchers and physicians alike are continuing to learn more about how this amazing compound interacts with the brain and the central nervous system to reduce pain and fight depression and other mood disorders. When administered by experienced experts like Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles, Ketamine Infusion Therapy is proving to be a powerful and highly effective treatment for a variety of painful and debilitating conditions such as osteoarthritis.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Coping with Stress and Anxiety With Cleaning

A Potential Strategy for Coping with Anxiety: Clean Your House!

shutterstock_156070412-300x200 Coping with Stress and Anxiety With Cleaning Los Angeles Southern CaliforniaIt sounds counterintuitive; after all, routine chores and never-ending housework can sometimes feel like just one more thing on an endless “to do” list. Yet it seems that for many people, housecleaning can actually provide a simple, easy way to help ease anxiety! In fact, cleaning offers a number of benefits when it comes to offering relief from worry and anxiety. In some cases, the act of itself cleaning may be the solution; cleaning requires a soothing, repetitive rhythm that can distract from and even calm a racing mind. For others, it’s the result that matters: studies show that a clean, well-organized living space can significantly reduce feelings of depression and anxiety.

If you are lucky, you’ve already discovered the soothing effect of cleaning in your everyday life. However, for the doubters among us, it turns out that this phenomena is actually backed by a variety of scientific studies. One of the most recent and most often cited, for example, was published in Current Biology in 2015. In this study, one group of students was told they needed to make a speech answering several questions; the other group was told they simply needed to think about the questions but not make a speech. Both groups were given a metal statue and asked to wipe it until clean. The group facing the prospect of public speaking cleaned the object more repetitively and more thoroughly than the control group.  

Here are the four main reasons why, if you are feeling stressed, worried, or anxious, taking the time to clean your house might actually make you feel better.

  • Cleaning as meditation

Cleaning involves smooth, repetitive, predictable movements such as pushing a mop back and forth across the floor, wiping a duster across the shelves, or circling a sponge across the countertop. As your mind focuses on these simple, task-driven movements, it can more easily block out the negative thoughts at the root of your anxiety. In other words, the repetitive act of cleaning can have a similar positive effect on the brain as more traditional types of meditation.

 

  • Cleaning provides a sense of control and order

Our living space is our sanctuary, and for many people, it can feel like the one place where we can control our environment. Cleaning up and organizing your living space puts you in control and empowers your choices. And of course, knowing where things are and being able to find the things you need exactly when you need them always reduces anxiety.

 

  • Cleaning offers tangible results

The tasks in our lives can seem endless and overwhelming with no end in sight. Cleaning can be easily broken down in a series of small steps with measurable, easily-visible results. In other words, when you are done cleaning the bathroom, you can see a clean, sparkling bathroom and “check it off the list”. That sense of satisfaction, of a job well done, provides a sense of accomplishment that counteracts anxiety and negative thinking.

 

  • A clean, well-organized home can reduce feelings of depression and stress

We’ve all experienced it: that sinking feeling when you walk in the door after a long busy day and see a pile of dirty dishes in the sink and heaps of clutter just lying around everywhere. Conversely, coming home to a clean, well-organized home can provide a sense of calm and orderliness. This is especially true for women: a 2010 study in Personality and Society Psychology Bulletin showed that women who described their homes as “cluttered” were more likely to be fatigued or depressed, and showed higher levels of the stress hormone cortisol.  

Next time you feel worried, stressed, or anxious and just can’t seem to relax, see if a little cleaning might restore your calm and ease your anxiety. Experts note that it’s important to start small and manageable.  Don’t try to clean the entire house at once, but set a small, achievable goal—mopping the kitchen floor, for instance, or organizing a bookshelf—and find out if this coping method works for you!

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is seeking help for an anxiety disorder, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if Ketamine Infusion Therapy may offer a solution.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

FDA Approves Esetamine Treatment for Treatment-Resistant Depression

Breaking news: the FDA has approved the use of Esketamine—a low-dose nasal ketamine spray—for the treatment of depression, PTSD, and other mood disorders!

FDA-approved-296x300 FDA Approves Esetamine Treatment for Treatment-Resistant Depression Los Angeles Southern CaliforniaFDA approval for Esketamine came less than one month after an FDA expert panel composed of psychiatrists and consumer representatives recommended (with nearly unanimous agreement) approval of the ketamine-based nasal spray, noting that its benefits significantly outweighed any potential risks. While low-dose ketamine treatments have been gaining recognition among physicians and psychiatrists over the past several decades, thus far the use of ketamine for depression and other mood disorders has been “off-label”. FDA approval of Esketamine offers a tremendous leap forward in the process of ensuring that this ground-breaking treatment is available to those who may benefit from it.

Esketamine is a low-dose ketamine-based nasal spray developed by Janssen Neuroscience, a subsidiary of Johnson & Johnson. With the recent FDA approval, it will now be sold under the brand name Spravato. According to official statements by Johnson & Johnson, Spravato is designed for patients who have tried at least two other forms of anti-depressants without success. The treatments will be administered only by qualified physicians or psychiatrists once or twice a week as needed to reduce depressive symptoms and suicidal ideation. Experts hope that with FDA approval, insurance companies will begin to cover Esketamine treatments, making them significantly more affordable and accessible.

FDA Approval Demonstrates that the Benefits of Ketamine Outweigh the Risks

FDA approval of Esketamine makes “official” what many experts in the field have long recognized: that low-dose ketamine treatments can deliver powerful and rapid relief from depressive symptoms and—most critically—suicidal thoughts. Physicians who have utilized low-dose ketamine treatments note that it can effectively reduce suicidal thinking sometimes in as little as 40 minutes. More “traditional” anti-depression treatments such as SSRIs can take up to six or eight weeks to “kick in” at full strength, creating an extremely long time period during which some patients may be at high risk of suicide. Low dose ketamine treatments offer a vital bridging tool during this high-risk period, when many patients simply don’t have time to wait for the anti-depressants to “kick in”.

In addition, ketamine has proven highly effective for some patients whose depressive symptoms have proven resistant to SSRIs and other “traditional” treatments. In fact, at Ketamine Clinics of Los Angeles, Dr. Steven L. Mandel has found that ketamine treatments offer relief from depressive symptoms 83% of the time, and are even more effective in stopping suicidal ideation, with successful treatments more than 90% of the time! These percentages, however, are for IV infusions. Although, Esketamine is a step in the right direction, IV infusions have still been proven to be more effective than nasal spray.

Moreover, low-dose ketamine treatments such as Esketamine appear to deliver powerful and effective results safely! When administered by qualified and experienced medical professionals in a safe and appropriate setting, ketamine treatments have very few negative side effects. In the longer term, low-dose ketamine treatments seem to carry very little risk of addiction or dependency. Therefore, for many patients suffering from treatment-resistant depression, PTSD, or other mood disorders, the benefit-risk analysis is definitely in favor of ketamine as a potential treatment option.

FDA approval of Esketamine is an important first step in recognizing what many patients and physicians already know: that low-dose ketamine offers a powerful tool in the fight against suicide, depression, PTSD, and mood disorders. We hope that as this vital tool becomes more widely available and outdated prejudices are overcome, that we will continue to see additional FDA approvals and more widespread use of this important treatment option.

Contact Ketamine Clinics of Los Angeles

If you or someone you love is struggling with depression, PTSD, or another mood disorder and you believe Ketamine Infusion Therapy might offer a solution, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to discuss this potential treatment option. Ketamine Infusion Therapy could be the solution you are searching for!

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Innovative RSD treatment with Low Dose Ketamine Infusion Treatments

Ketamine Infusion Therapy: An Innovative Treatment Option for RSD / CRPS

 

CRPS/RSD is usually caused by nerve and tissue damage stemming from a trauma such as a musculoskeletal or nerve injury, surgery, or extended immobilization. As the damaged nerves misfire or otherwise malfunction, they send constant pain signals to the brain, leading to the severe, chronic pain that characterizes this syndrome. Generally speaking, symptoms of CRPS/RSD may include:

  • Pain that is more severe than the original injury/trauma and/or does not subside with healing
  • Pain that is deep, cold or burning, aching, and/or involves increased skin sensitivity
  • Moderate-to-severe pain stemming from unusual sources (such as wearing clothing)
  • Moderate-to-severe pain that continues after exposure to painful stimulation
  • Abnormal swelling in the affected area
  • Abnormal skin changes, such as change in color or temperature, or temperature differentials across the body
  • Abnormal sweating
  • Abnormal nail and/or hair growth
  • Temporary or limited paralysis, range of motion, and/or weakness

Unfortunately, as of right now, there is no way to “cure” this chronic condition; however, with appropriate and well-coordinated treatment, it is possible to manage symptoms and reduce and even relieve the pain to enable CRPS/RSD sufferers to return to their healthy, active lifestyle.

 

Is Ketamine an Appropriate Treatment Option for CRPS/RSD?

Low dose Ketamine Infusion Therapy may offer an innovative new treatment option for individuals suffering from this debilitating syndrome. While ketamine has long been accepted by the medical community as a fast-acting and highly-effective anesthetic, new research clearly indicates ketamine’s effectiveness in treating chronic pain when administered in sub-anesthetic doses. Moreover, ketamine can deliver powerful pain relief without the negative side effects and potential problems associated with more traditional treatment options such as narcotics and opioids.

While research on the benefits of ketamine as a treatment for chronic pain is ongoing, it is currently believed that ketamine works by resetting the central nervous system’s sensitization to pain. In other words, ketamine calms the nerves themselves, thus raising the threshold at which the body’s neurons start sending pain signals to the brain. The higher threshold for pain signals reduces the number of pain signals sent to the brain, leading to an overall reduction in the pain experienced by individuals with CRPS/RSD.

Low dose Ketamine Infusion Therapy for CRPS/RSD involves a series of ketamine infusions followed by maintenance infusions at longer intervals to ensure long-term pain relief. Infusions involve slowly administering ketamine directly into the bloodstream through an IV. At Ketamine Clinics of Los Angeles, a state-of-the-art clinic accredited by AAAASF, we utilize digital infusion pumps to deliver precisely tailored dosages that can be changed extremely rapidly as each patient responds to the treatment. Each treatment plan and individual infusion is uniquely tailored to meet the needs of every individual depending on their specific diagnosis and overall health.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love has been diagnosed with CRPS / RSD and you believe Ketamine Infusion Therapy might offer pain relief, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if Ketamine Infusion Therapy is an appropriate treatment option.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

 

SPRAVATO™ (esketamine) – Nasal Spray, Now FDA Approved‎

A Ketamine-Based Nasal Spray For Depression Has Just Been Approved by The FDA

SPRAVATO-esketamine-Nasal-Spray-FDA-Approved‎-300x240 SPRAVATO™ (esketamine) - Nasal Spray, Now FDA Approved‎ Los Angeles Southern CaliforniaThe Food and Drug Administration approved a novel antidepressant late Tuesday for people with depression that does not respond to other treatments – the first in decades to work in a completely new way in the brain.

The drug, a nasal spray called esketamine, has been eagerly anticipated by psychiatrists and patient groups as a powerful new tool to fight intractable depression.

The spray acts within hours, rather than weeks or months as is typical for current antidepressants, and could offer a lifeline to about 5 million people in the United States with major depressive disorder who haven’t been helped by current treatments. That accounts for about 1 in 3 people with depression.

What is SPRAVATO (esketamine) Nasel Spray?

SPRAVATOTM is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

SPRAVATOTM is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATOTM is safe or effective as an anesthetic medicine. Read more

 

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

As Seen On

Contact Us

Ketamine Clinics of Los Angeles
6801 Park Terrace, Suite 525
Los Angeles, CA 90045
P: 310-270-0625
F: 310-730-5993
Monday - Friday: 9:00 am - 5:00 pm
Ketamine Clinics of Los Angeles Location

Please Specify Referral Source*

or