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Innovative RSD treatment with Low Dose Ketamine Infusion Treatments

Innovative RSD treatment with Low Dose Ketamine Infusion Treatments

Ketamine Infusion Therapy: An Innovative Treatment Option for RSD / CRPS

 

CRPS/RSD is usually caused by nerve and tissue damage stemming from a trauma such as a musculoskeletal or nerve injury, surgery, or extended immobilization. As the damaged nerves misfire or otherwise malfunction, they send constant pain signals to the brain, leading to the severe, chronic pain that characterizes this syndrome. Generally speaking, symptoms of CRPS/RSD may include:

  • Pain that is more severe than the original injury/trauma and/or does not subside with healing
  • Pain that is deep, cold or burning, aching, and/or involves increased skin sensitivity
  • Moderate-to-severe pain stemming from unusual sources (such as wearing clothing)
  • Moderate-to-severe pain that continues after exposure to painful stimulation
  • Abnormal swelling in the affected area
  • Abnormal skin changes, such as change in color or temperature, or temperature differentials across the body
  • Abnormal sweating
  • Abnormal nail and/or hair growth
  • Temporary or limited paralysis, range of motion, and/or weakness

Unfortunately, as of right now, there is no way to “cure” this chronic condition; however, with appropriate and well-coordinated treatment, it is possible to manage symptoms and reduce and even relieve the pain to enable CRPS/RSD sufferers to return to their healthy, active lifestyle.

 

Is Ketamine an Appropriate Treatment Option for CRPS/RSD?

Low dose Ketamine Infusion Therapy may offer an innovative new treatment option for individuals suffering from this debilitating syndrome. While ketamine has long been accepted by the medical community as a fast-acting and highly-effective anesthetic, new research clearly indicates ketamine’s effectiveness in treating chronic pain when administered in sub-anesthetic doses. Moreover, ketamine can deliver powerful pain relief without the negative side effects and potential problems associated with more traditional treatment options such as narcotics and opioids.

While research on the benefits of ketamine as a treatment for chronic pain is ongoing, it is currently believed that ketamine works by resetting the central nervous system’s sensitization to pain. In other words, ketamine calms the nerves themselves, thus raising the threshold at which the body’s neurons start sending pain signals to the brain. The higher threshold for pain signals reduces the number of pain signals sent to the brain, leading to an overall reduction in the pain experienced by individuals with CRPS/RSD.

Low dose Ketamine Infusion Therapy for CRPS/RSD involves a series of ketamine infusions followed by maintenance infusions at longer intervals to ensure long-term pain relief. Infusions involve slowly administering ketamine directly into the bloodstream through an IV. At Ketamine Clinics of Los Angeles, a state-of-the-art clinic accredited by AAAASF, we utilize digital infusion pumps to deliver precisely tailored dosages that can be changed extremely rapidly as each patient responds to the treatment. Each treatment plan and individual infusion is uniquely tailored to meet the needs of every individual depending on their specific diagnosis and overall health.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love has been diagnosed with CRPS / RSD and you believe Ketamine Infusion Therapy might offer pain relief, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if Ketamine Infusion Therapy is an appropriate treatment option.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

 

SPRAVATO™ (esketamine) – Nasal Spray, Now FDA Approved‎

A Ketamine-Based Nasal Spray For Depression Has Just Been Approved by The FDA

SPRAVATO-esketamine-Nasal-Spray-FDA-Approved‎-300x240 SPRAVATO™ (esketamine) - Nasal Spray, Now FDA Approved‎ Los Angeles Southern CaliforniaThe Food and Drug Administration approved a novel antidepressant late Tuesday for people with depression that does not respond to other treatments – the first in decades to work in a completely new way in the brain.

The drug, a nasal spray called esketamine, has been eagerly anticipated by psychiatrists and patient groups as a powerful new tool to fight intractable depression.

The spray acts within hours, rather than weeks or months as is typical for current antidepressants, and could offer a lifeline to about 5 million people in the United States with major depressive disorder who haven’t been helped by current treatments. That accounts for about 1 in 3 people with depression.

What is SPRAVATO (esketamine) Nasel Spray?

SPRAVATOTM is a prescription medicine, used along with an antidepressant taken by mouth, for treatment-resistant depression (TRD) in adults.

SPRAVATOTM is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATOTM is safe or effective as an anesthetic medicine. Read more

 

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

New Guidelines Support the Use of Low Dose Ketamine Infusions for Acute and Chronic Pain

Low Dose Ketamine Infusions for Acute and Chronic Pain Guidelines

shutterstock_57069928-200x300 New Guidelines Support the Use of Low Dose Ketamine Infusions for Acute and Chronic Pain Los Angeles Southern CaliforniaFirst developed in the early 1960s, ketamine has been an FDA-approved anesthetic since 1970 and has been widely accepted as an appropriate anesthetic in some limited contexts, such as battlefield medicine, for many years. However, the medical community has been reluctant to embrace the use of ketamine more widely as a potential treatment for either acute or chronic pain. Luckily, this trend has begun to change; in recent decades, ketamine has been being “rediscovered” as a powerful, inexpensive, and highly-effective tool in the medical community’s tool-kit.

In a huge step forward, a well-respected group of physicians has issued a set of guidelines for the use of ketamine in the treatment of acute pain, while noting ketamine’s potential benefits for the use of chronic pain. The guidelines were spearheaded by the American Society of Regional Anesthesia and Pain Medicine and the American Academy of Pain Medicine, while the American Society of Anesthesiologists’ Committees on Pain Medicine and Standards and Practice Parameters approved the guidelines document. The document notes that research increasingly supports the safe and effective use of low dose IV ketamine infusions in a variety of contexts, either as a stand-alone treatment option or in conjunction with opioid-based pain management.

The guidelines address two specific issues: when ketamine should be considered an appropriate treatment option and at what dosages (noting that dosages are highly dependent on each unique individual). For instance, the guidelines note that sub-anesthetic ketamine infusions should be considered for patients undergoing inpatient or outpatient surgery. For patients who are opioid-dependent or opioid-tolerant, the guidelines state that low dose ketamine infusions may be appropriate in surgical situations, as a treatment for acute or chronic sickle cell pain, or who are coping with sleep apnea. The guidelines also note some exceptions when ketamine may not be appropriate, such as patients with poorly-controlled cardiovascular or liver disease, patients with active psychosis, and pregnant women.  

 

Ketamine as an Alternative to Opioids

Of course, the greatest benefit of Ketamine Infusion Therapy—the administration of low doses of ketamine directly into the bloodstream through an IV—as a treatment for either acute or chronic pain is simply that it works, and it works safely! However, the authors of the new guidelines stressed another benefit to this “revolutionary” treatment: it offers an alternative to the highly addictive opioid-based pain treatments on which the medical community has depended for the treatment of pain since the early 1990s. Unfortunately, it is now becoming generally accepted that the use of opioid pain medication has played a critical role in the rise of the opioid epidemic facing the United States today.

Thus, as the medical community searches for methods of treating and managing both acute and chronic pain while minimizing, or even avoiding altogether, opioid-based prescriptions, these new guidelines support the idea that ketamine could offer a potential alternative. Ketamine does not have any long-term side effects risk of addiction when administered properly by a qualified medical practitioner. It is an especially attractive alternative for patients who have a history of opioid addiction, who are opioid-dependent or opioid-tolerant, or for whom opioid medications are simply not appropriate.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is struggling with chronic pain and you believe Ketamine Infusion Therapy might offer a solution, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to discuss this potential treatment option. Ketamine Infusion Therapy could be the solution you are searching for!

Please visit our website at ketamineclinics.com or contact us at 424-343-8889 to schedule an appointment.

We monitor your depression levels before, during, and after Ketamine treatments

Ketamine Infusion Therapy for Depression: Short- and Long-Term Monitoring for Lasting Results

shutterstock_79372534-199x300 We monitor your depression levels before, during, and after Ketamine treatments Los Angeles Southern CaliforniaClinical depression is the second most common form of mental illness in the United States after anxiety disorders, and may impact as many as 16 million Americans annually. Clinical depression can be difficult to recognize at first; after all, everyone goes through periods where they are sad or moody. Yet for many individuals, depression causes significant emotional and can physical distress, and can undermine ones ability to function in normal situations, such as work, school, and social settings.  

Over the past several decades, a well-known anesthetic known as ketamine has emerged as a new and highly successful treatment options for individuals suffering from depression and other mood disorders. Unlike traditional antidepressants, which can take days and even weeks to “kick in”, Ketamine Infusion Therapy offers many patients immediate relief from depressive symptoms. More importantly, ketamine can deliver relief from depressive symptoms over the long term, including patients for whom traditional antidepressants have not proven effective.  

How do we know ketamine works? We know it works because our patients tell us it works. At Ketamine Clinics of Los Angeles, Dr. Steven L. Mandel has developed a reliable, sustainable monitoring methodology that enables him to regularly assess the long term impact of ketamine treatments on his patients. Dr. Mandel utilizes these regular assessments to modify the original treatment plan as needed to ensure his patients’ long term mental health.    

 

Our Assessment Methodology: How We Monitor Results of Ketamine Infusion Therapy Treatments

Dr. Steven L. Mandel’s successful assessment methodology is centered on his unique Mood Monitor, a HIPPA-compliant encrypted assessment service via text messaging that makes routine communication and assessment with each client easy to complete, while maintaining our patients’ confidentiality and safety. The Mood Monitor uses the PHQ-9 (a standard depression assessment tool) that asks patients to rank their mood, feelings, and activities across 10 basic questions. The “score” of each PHQ-9 assessment indicates the severity of the patient’s depression, from severe to mild or none.

Through Mood Monitor, each patient takes the PHQ-9 starting with an initial diagnostic assessment, before each infusion, and then into the maintenance phase every two weeks. Each PHQ-9 score is graphed onto an easily-readable chart. Most patients start with a score “in the red”, which indicates severe depression. As the ketamine infusions take hold, each successive PHQ-9 score is plotted onto the chart. Most patients will see their graphed scores as a line showing an upward trajectory on the chart as they experience continued relief from their depressive symptoms: from severe or moderately severe, to moderate, mild, and then “green” indicating no depressive symptoms.

Our goal—aided by regular assessments through Mood Monitor—is to help all patients land in that “green” zone and then stay there. Some patients find that relief immediately and require none or perhaps minimal booster treatments to maintain long term results. For other patients, it might take longer to see those results, or it may require more regular or more frequent booster treatments to maintain long term mental health. Through our regular, long term monitoring methodology, we can easily and effectively develop unique treatment plans for each patient, depending on their response to treatment and long term mental health needs.

To see several sample charts indicating actual patient results, we encourage you to visit our website at

https://www.ketamineclinics.com/treatment-results/.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is struggling with depression and you believe Ketamine Infusion Therapy might offer a solution, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Ketamine helps ease anxiety quickly

Ketamine Infusion Therapy and Anxiety Disorders

shutterstock_23599909-200x300 Ketamine helps ease anxiety quickly Los Angeles Southern CaliforniaWe all feel anxious or nervous occasionally. Our everyday lives present us with plenty of stressful situations where anxiety is normal, and can even be helpful, such as a job interview, a test or exam, a first date, or even making an important decision. In these types of situations, it is normal to feel a heightened sense of anxiety as the stressful event draws closer, but then the anxiety fades as the situation passes.

Anxiety disorder is different. For individuals suffering from an anxiety disorder, feelings of anxiety and panic are more than a temporary response to a stressful event. Instead of dissipating as we cope with a stressful situation, the anxiety does not go away; in fact, for many individuals with anxiety disorder, the feelings of anxiety and panic actually grow stronger over time.

The most common types of anxiety disorder include:

  • Generalized Anxiety Disorder (GAD): excessive worry or anxiety most days over a six month period about generally routine events
  • Panic Disorder: recurrent panic attacks brought on unexpectedly or because of a specific trigger
  • Phobia-related Disorder: intense fear or aversion to specific objects or situations, out of proportion to the actual danger that object or situation presents
  • Social Anxiety Disorder: general intense fear of situations that require interacting with or performing in front of others
  • Agoraphobia: intense fear of being outside, being in a crowd, using public transportation, and/or being in open or closed spaces
  • Separation Anxiety Disorder: intense fear of being separated from an attachment figure or being alone

Ultimately, the difference between a normal feeling of anxiety and an anxiety disorder is the fact that for people with an anxiety disorder, the anxiety can become so crippling that it impedes his or her ability to cope with normal activities such as a job, school, and even relationships.

 

Ketamine Eases Anxiety Quickly and Effectively

A variety of studies—as well as significant anecdotal evidence—now suggest that ketamine has an immediate anti-depressive effect for individuals suffering from depression and PTSD. Researchers are now also exploring whether ketamine may also have similar benefits for individuals with anxiety disorders, especially individuals for whom traditional pharmacological treatments have not proven effective. Ketamine Infusion Therapy, it is believed, can offer rapid relief from anxiety symptoms, and even help ameliorate anxiety over the medium- and even long-term.

A 2017 study published in the Journal of Psychopharmacology, for instance, suggests that Ketamine Infusion Therapy may provide immediate and highly effective relief from anxiety disorders. In this study, 12 individuals with treatment-resistant anxiety who were not also suffering from depression or another mood disorder were given three doses of ketamine once per week. The three doses were all given in sub-anesthetic quantities but in increasing amounts throughout the week. The majority of patients in the study showed an immediate decrease in anxiety-related symptoms, with the relief lasting upwards of seven days after the last infusion.

A 2018 study, also published in the Journal of Psychopharmacology, looked at ketamine’s potential as a maintenance treatment for patients with treatment-resistant anxiety disorders. This study followed 20 individuals with treatment-resistant anxiety disorder who had a prior positive response to Ketamine Infusion Therapy. These patients received one or two Ketamine Infusion Therapy treatments per week for three months. Again, the majority of patients in this study showed immediate relief from anxiety symptoms after each treatment, while experiencing minimal side effects.

As these studies clearly demonstrate, Ketamine Infusion Therapy holds great promise as a fast-acting treatment option for individuals with treatment-resistant anxiety.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is seeking help for an anxiety disorder, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

We encourage you to visit our website at https://www.ketamineclinics.com/ or contact us at 424-343-8889 to schedule an appointment.

Ketamine may rapidly relieve depression by blocking overstimulation of the lateral habenula

shutterstock_8492125-300x300 Ketamine may rapidly relieve depression by blocking overstimulation of the lateral habenula Los Angeles Southern CaliforniaKetamine and the Lateral Habenula, the Brain’s Reward Center

The medical community is increasingly excited by the ever-growing body of scientific literature exploring the unique anti-depressive effects of the well-known anesthetic ketamine. Many of these studies have focused on the effectiveness of Ketamine Infusion Therapy—a type of treatment in which ketamine is slowly delivered directly into the blood stream in sub-anesthetic doses—and the results are promising: they demonstrate that most patients experience a very rapid decrease in depressive symptoms, while experiencing minimal negative side effects.

What seems to be less well understood is how ketamine interacts with the brain to relieve depression. Some studies have focused on ketamine’s role as an NMDA receptor antagonist and an AMPA receptor stimulator guiding levels of the neurotransmitter glutamate within the brain. Other studies seem to indicate that ketamine may activate the opioid system in addition to the glutamate system.

Most recently, an article published in Nature suggests that ketamine may have an entirely different mechanism of action. This study suggests that ketamine may work by blocking bursts of neuron activity in the lateral habenula; overstimulation of the lateral habenula seems to be linked to depression and depressive symptoms. This exciting study offers yet more evidence that Ketamine Infusion Therapy may indeed present one of the greatest breakthroughs in the treatment of depression in recent decades!

 

What is the lateral habenula and how is it linked to depression?

The lateral habenula is one of two small swellings found in the epithalamus area of the brain, near the pineal gland (the two swellings together are the habenulae, traditionally divided into the lateral and medial habenula.) The habenulae seem to be one of the areas of the brain responsible for reward processing because of its involvement in the release of dopamine and serotonin. Put simply, when our brain receives a “reward”, the brain increases dopamine activity, which helps the brain remember that reward as a positive stimulus. When a reward is smaller than expected, the habenula seems to become more excited, while when the reward is larger than expected, the habenula seems to become less excited. Moreover, the habenula seems to become more activated when we respond to a punishment or negative stimuli; therefore, scientists hypothesize that the lateral habenula in particular is responsible for helping us learn how to avoid negative or unpleasant experiences.

Although the exact mechanisms are not as yet fully understood, there seems to be a link between hyperactivity in the lateral habenula and the pathophysiology of depression. There is some evidence that neurons within the lateral habenula have excessive bursts of activity during episodes of depressive symptoms. In some cases, structural abnormalities of the lateral habenula have been identified in some individuals suffering from severe depressive disorders. In other words, evidence from both animal and human studies seems to indicate that overstimulation of the lateral habenula may be associated with depressive symptoms, including helplessness, lack of pleasure, pessimism, and general depression.

 

How Does Ketamine Impact the Lateral Habenula and Depression?

The recent study published in the journal Nature hypothesizes that ketamine may work by blocking the bursts of activity within the lateral habenula driving depressive symptoms and depression. The study theorizes that the increased burst-like firing of neurons in the lateral habenula are driven by NMDA receptor activity; therefore, as an NMDA receptor antagonist, ketamine helps to prevent these particular neurons from firing inappropriately. In other words, its ability to block the brain’s overactive response to negative stimuli may explain its rapid anti-depressive impact on the brain. This exciting avenue of research is likely to lead to a far greater understanding of the complex mechanisms of the brain, especially as related to depression, mental illness, and mood disorders, which in turn will offer us truly promising treatment options—like Ketamine Infusion Therapy—for individuals whose lives have been disrupted by depression and other mental illness.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is struggling with depression and you believe IV Ketamine Infusion Therapy might offer a solution, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

Please visit our website at https://www.ketamineclinics.com/ or contact us at 424-343-8889 to schedule an appointment.
For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Study shows Ketamine is neuroprotective and can prevent brain damage

shutterstock_120206599-249x300 Study shows Ketamine is neuroprotective and can prevent brain damage Los Angeles Southern CaliforniaStudy Shows Ketamine May Help Prevent Brain Damage after Trauma or Stroke

Over the past several decades, scientists have made significant advances in understanding how the brain functions. Yet despite this progress, medical science has yet to develop a successful strategy for reducing brain damage during stroke or trauma brain injury (TBI). Most medical intervention today is focused on mitigating the potential for delayed injury occurring hours or days after the event. Development of a medical approach that could treat primary injury—the instantaneous damage done to the brain during the stroke or injury—would indeed be a tremendous breakthrough.

A 2017 study in Anesthesia & Analgesia suggests that ketamine, a well-known anesthetic, may, in fact, act as a “neuroprotective” agent that can actually protect the delicate cells of the brain from injury and premature death due to stroke or traumatic injury. As our knowledge of ketamine as a NMDA receptor antagonist improves, ketamine is increasingly viewed as a potential new treatment option for an increasingly wide range of medical conditions, such as depression, PTSD, and mood disorders, as well as chronic pain. This study reviews ketamine’s usefulness as an intervention mechanism to slow and even prevent primary brain damage immediately following stroke or TBI.

Ketamine’s potential as a neuroprotective agent may stem from the multitude of ways it interacts with the neurons and synapses of the brain at the cellular level. Because of the complexity of the brain itself, cell injury and death during and immediately after stroke or TBI is perpetuated by a chain of neurotoxic processes, each of which must be addressed in order to stave off additional damage. This study reviews the methods by which ketamine may successfully intervene in several of the most important neurotoxic processes in order to protect the brain when it is at its most vulnerable.

 

  • Excitotoxicity

Excitotoxicity is an extreme state of deregulation within the brain caused by a build-up of calcium within the damaged synapses (a profound simplification of an extremely complex process). Decreased blood flow due to trauma can cause excess glutamate to accumulate, setting off a complex chain of events that can—ultimately—impair the delivery of oxygen and glucose, create an imbalance in sodium levels, and ultimately cause the brain to pump too much calcium into the damaged neurons. Ketamine may mitigate excitotoxicity by “antagonizing” (reducing) the release of excess glutamate, thereby reducing the influx of calcium. Ketamine may also work to increase blood flow to the damaged areas, thereby addressing a root cause of excitotoxicity in the first place.

 

 

  • Apoptosis

Apoptosis is the process of cellular death that occurs because a cell “decides” (for lack of a better term) to die prematurely (versus a cell that has died specifically due to injury or damage, called necrosis). It is believed that ketamine may reduce apoptosis and premature cellular death by upregulating the protein B-cell lympthoma 2 during brain trauma; B-cell lympthoma 2 is responsible for promoting cell survival. Studies have also shown that ketamine may inhibit apoptosis by reducing the influx of chemicals such as adrenaline, noradrenaline, and dopamine into the brain, as the presence of these chemicals has been linked to negative outcomes in some cases of brain trauma.

 

 

  • Neuro-inflammation

Researchers believe that one of ketamine’s most important properties—especially in terms of mitigating damage due to stroke or TBI—is its anti-inflammatory effects. First, ketamine may restrict the permeability of the blood-brain barrier, protecting the brain from the potentially damaging impacts of elevated levels of white blood cells (which the body uses to fight infection). Second, ketamine may inhibit the activation of certain cells and proteins that the body naturally releases to mitigate tissue damage. By interrupting the body’s normal response to cell damage in these ways, ketamine may play an important role in combatting damaging inflammation relating to stroke and TBI.

 

 

  • Microthrombosis

A common concern after stroke or TBI is microthrombosis, the build-up of platelets (a type of blood cell) within the tiny vessels of the brain, potentially blocking oxygen and glucose from reaching the neurons. Ketamine has been shown to have a highly beneficial impact on disrupting microthrombosis during cardiopulmonary bypass procedures, and scientists believe a similar impact may mitigate the damaging processes of platelet accumulation during stroke and TBI as well.

We still have much to learn about how ketamine affects our critical brain processes, but it is increasingly apparent that it holds a great deal of promise as a highly-effective treatment for a variety of serious injuries and ailments. If, as this study suggests, ketamine holds the key to successfully addressing the immediate damage to the brain caused by stroke or traumatic brain injury, it will be a medical breakthrough with truly significant implications for the health and well-being of millions of Americans.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is seeking help for depression, PTSD, or another form of mood disorder, or coping with chronic pain, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

We encourage you to visit our website at https://www.ketamineclinics.com/ or contact us at 424-343-8889 to schedule an appointment.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Celebrating Five Years of Patient Success!

unnamed-289x300 Celebrating Five Years of Patient Success! Los Angeles Southern CaliforniaLETTER FROM DR. MANDEL

Have you been able to keep warm this February? Being located in sunny Southern California I know that I have no place to complain about being cold, however, I am blown away by how chilly this season has been! This morning my car did not start because the battery froze, I could not believe it! Across the country we are experiencing record breaking weather. Temperatures have reached so low in some areas that people are being encouraged to not leave their home. I don’t remember a time in my life where I witnessed -48 degrees listed on a weather report. This is groundbreaking. These conditions become problematic for some when schools and companies close, truck drivers can’t make deliveries timely, and air travel suffers numerous delays and cancellations. My hope is that you remain safe and warm during this winter time. Here’s wishing that the groundhog was right and spring will show up early for us this year!

What I can appreciate is that with the cold brings endless fluffy snow to the mountain tops, just in time for our annual family ski trip at the end of the month! Skiing fresh powder slopes is something I look forward to every year. Quality time with the family in a cozy cabin warms my heart and is rejuvenating. For me, these below zero temperatures equal a week of fun, but for many people, it’s numerous days of gloom and being home bound. With the limitations of winter comes increased mood swings and depression. Stay in-tune with how you are feeling during this time, and if we can be of any help please do not hesitate to give us a call.

Lastly, the end of January marked the 5 year anniversary of Ketamine Clinics of Los Angeles. My son Sam and I embarked on this adventure over 5 years ago and what a journey it has been! Together, we took a treatment that we knew could save lives and pressed on endlessly to get it recognized and available to the masses. I am so very proud of what we accomplished over the years. Our team has grown from the two of us to a highly compassionate and driven staff of 10. We continue to raise awareness and work to heal and treat depression, other mood disorders, and chronic pain. This is my calling, and thus far has been the most rewarding work I have ever done.

Dr. Mandel


unnamed-1-300x225 Celebrating Five Years of Patient Success! Los Angeles Southern CaliforniaHAPPY 5 YEARS TO US!

Ketamine Clinics of Los Angeles Commemorates Five Years of Patient Success Stories.

PRESS RELEASE

Leading IV Ketamine Infusion Treatment Provider Offers Hope Among America’s Depression and Suicide Epidemic

“LOS ANGELES, Jan. 29, 2019 /CNW/ — The world’s largest and most specialized ketamine treatment facility, Ketamine Clinics of Los Angeles, celebrates its five-year anniversary with more than 8,000 successful infusions administered, over 1,200 patients cared for, and a brand new 3,600-square foot Class-A facility. Today, Ketamine Clinics of Los Angeles is not only the country’s leading provider of the breakthrough treatment, but, its founder, Dr. Steven L. Mandel, has been an internationally recognized pioneer in ketamine therapy for years now, helping drive greater awareness for this medicine’s proven ability to treat depression, suicidality, PTSD, and pain conditions.” Read more.

unnamed-1-1-300x205 Celebrating Five Years of Patient Success! Los Angeles Southern CaliforniaOur wonderful team celebrating our
5 year milestone over dinner at
The Wallace in Culver City


SPOTLIGHT ON DR. MANDEL!

Featured in Inc.
Video games and ketamine are among the new and novel treatment options startups are developing. Read more

Podcast with Lisa Davis!

Steven L. Mandel, MD joins Lisa to talk about the treatment of suicidal thoughts, depression, and PTSD with Ketamine Therapy. Listen now
Quoted in Bloomberg

Ketamine could be the Key to Reversing America’s Rising Suicide Rate. Read more


Trauma, Stress, and More Linked to Depressive Disorders in College Freshmen

“Major depressive disorder (MDD) occurs in 6.9% of first-year college students, and the strongest baseline predictors at the population level were history of trauma, parental psychopathology, recent stressful experiences, and other mental disorders in the past year, according to study results published in Depression & Anxiety.” Read more


Why Cleaning Makes Some People Feel Less Anxious

“For a certain type of person, taking a few minutes to whisk the Swiffer Wet across the kitchen floor can feel akin to the soothing effects of meditation. Even the sight of a spotless home, especially at the end of a long, stressful day, can temporarily seem to blunt whatever’s bothering them. ” Read more

Repurposing old drugs like Ketamine can save time and money

shutterstock_26543428-300x200 Repurposing old drugs like Ketamine can save time and money Los Angeles Southern CaliforniaFinding New Purposes for “Old” Drugs Means Saving Time and Money

We hear a lot in the media these days about the outrageous and sometimes prohibitive cost of prescription medication. What we don’t often hear about is the amount of time and money it takes to develop new, effective, and safe medications. It can cost anywhere from $1 billion to $2 billion to research, develop, test, and produce just one new drug, and the process can take anywhere from 10 to 12 years! Unfortunately, fewer than 20% of medications on the market actually generate enough revenue to cover those costs.

Luckily, sometimes medications themselves present an answer to this troubling dilemma: when an existing medication offers an unexpected solution to a different problem than that for which it was designed. There are numerous examples: sildenafil and minoxidil were both created to treat cardiovascular issues; sildenafil has been repurposed as Viagra to treat erectile disfunction and minoxidil has been repurposed as Rogaine to fight male pattern baldness. Mecamylamine, valsartan, and ropinirole are long-standing treatments for high blood pressure but are being repurposed as potential treatments for depression, Alzheimer’s disease, and Parkinson’s disease (respectively). The list could go on.

There are a variety of benefits to repurposing existing medications in this way. Finding a new purpose for an existing drug may literally cut years off the development cycle, providing a necessary shortcut for an industry with a high rate of failure (only about 10% of new drugs actually go on to be approved by the FDA). Shortening the development time for a drug can also cut the price tag, saving hundreds of thousands of dollars each year in research costs. The most important benefit, however, may be the fact that with existing medications, the side effects are already well-known and established.  

 

Repurposing Ketamine: An “Old” Anesthesia Presents a New Treatment Option for Mood Disorders

Ketamine is an excellent example of a long-standing medication that is now being “repurposed” for a variety of different—and important—uses. First approved by the FDA in 1970, ketamine has a long and well-established history as an anesthetic, first being used as a field anesthetic during the Vietnam War; its ease of administration and ability to work quickly, safely, and effectively played a key role in helping injured soldiers survive until they could get to a field hospital. It is still used as a safe and effective anesthetic in some surgical situations, as well as in veterinary medicine.

Ongoing research into the mechanisms through which ketamine impacts the brain are opening up some amazing potential uses for this well-known drug. When administered in sub-anesthetic doses directly into the blood stream—known as IV Ketamine Infusion Therapy—ketamine has been shown to have an immediate anti-depressive effect. This potential therapy for depression, PTSD, and other mood disorders is especially promising for individuals for whom traditional anti-depressants have not proven effective. It is also promising as an emergency intervention for individuals who simply cannot wait for traditional anti-depressants to “kick in” and stop cycles of negative thinking and suicidal ideation.

Its long history has shown that ketamine is safe and highly effective, with minimal effects, making it especially promising as a “repurposed” medication. As research continues into the benefits of IV Ketamine Infusion Therapy as a possible alternative to opioids, we will likely add yet one more medication to the list of those that have been successfully “repurposed”!

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is seeking help for depression, PTSD, or another form of mood disorder, or coping with chronic pain, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

We encourage you to visit our website at https://www.ketamineclinics.com/ or contact us at 424-343-8889 to schedule an appointment.
For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

Ketamine Helps Divers Rescue Soccer Team Stranded in Flooded Thai Cave

iStock_000004402639Medium-200x300 Ketamine Helps Divers Rescue Soccer Team Stranded in Flooded Thai Cave Los Angeles Southern CaliforniaKetamine Helps Divers Rescue Trapped Soccer Team

For three long weeks in early summer 2018, the entire world watched, breathless but hopeful, as a dedicated team of specialists achieved the impossible: safely rescuing an entire soccer team from deep within a flooded cave system. The “Wild Boars”—a Thai soccer team composed of 12 boys between the ages of 11 and 17 and their 25-year-old coach—seemingly vanished one afternoon after a practice. After a desperate two-week-long search, they were finally located—alive but trapped—deep within a cave system known as Tham Luang Nang Non.

A well-known tourist destination in northern Thailand, the cave was dry when the boys started their afternoon adventure, and they were able to navigate several kilometers into the cave system without difficulty. They anticipated being able to simply turn around and walk out the way they came in. They were not anticipating the heavy rain, however, which quickly flooded the low-lying areas of the cave system and blocked their exit. By the time they were discovered by a team of Thai divers two weeks later, they were alive, but weak and malnourished.

Thai Navy Seals, assisted by military teams from the United States, Great Britain, and Australia, quickly set up supply lines to bring the boys food and clean water, along with medical personnel to monitor their health. Pumps were brought in to keep the cave from flooding further, and efforts were made to pump the flooded areas dry so the boys could walk out as they walked in. It quickly became apparent, however, that the only potential option for getting the boys out was to dive them through the flooded areas. Everyone understood that although it was the best option, it was extremely risky.

In theory, the plan was simple: four British divers with specific expertise in underwater cave rescue would dive one boy each through the flooded areas, assisted by support teams and carefully-placed supplies along the way. In reality, however, the plan was fraught with danger, where a single mistake or accident could cost both the boy and the diver their lives. One expert diver—a Thai Navy Seal—had already died while bringing in supplies for the trapped boys.

While the team carefully planned and practiced every single aspect of the rescue attempt in order to eliminate any potential for surprise, they were faced with one element they could not control: the boys themselves. The expert divers especially were concerned about the possibility that the boys might panic during the dive, when any sudden, unexpected, or uncontrolled movement could spell disaster. It would only work, they insisted, if the boys were unconscious throughout the entire dive.

Australian anesthesiologist and rescue diver, Dr. Richard Harris, had the answer: ketamine. Ketamine has a long history as an emergency anesthetic; for example, it was used heavily as a battlefield anesthetic during the Vietnam War, and. It seemed ideally suited for this unique situation: fast-acting, easy-to-administer, very safe for use with children, and highly effective. Because ketamine is also a short-duration anesthetic—with the effects of a single injection wearing off after about 45 minutes—the divers would need to re-administer injections throughout the long journey out of the cave.

With this final detail in place, the rescue began, with the boys themselves deciding who would go first. After dressing in a wetsuit, the first boy was given an injection of ketamine to calm him and put him into a sedative state. He was then fitted with a full-face diving mask attached to an oxygen tank, which would allow him to breathe normally. Once in the water, the diver supported and guided him with one hand while holding a guide rope with the other, switching hands as necessary to carefully swim through the dark, narrow passages. The next team—diver and sedated boy—left about 45 minutes later, with the goal of rescuing four boys per day until everyone was out of the cave.

It took each team more than four hours to navigate the approximately four kilometers from the ledge where the boys were trapped to the cave entrance. At the first sign of movement or emergence from the sedative state, the divers administered another ketamine injection, often when standing in deep, flowing water, to ensure that the boy remained calm and asleep throughout the trip. Once out of the cave, each boy was rushed by ambulance to a waiting hospital to be assessed and monitored for health concerns, particularly respiratory infection which was the greatest risk after more than 16 days in a damp cave.

Miraculously, the divers and support teams successfully rescued all 12 boys and their coach over three intense and exhausting days. As this amazing story shows, ketamine continues to play an important role as an emergency anesthetic. As we learn more about how ketamine works, we continue to discover additional ways in which this drug can promote both physical and mental health. Today, the medical community is recognizing ketamine’s potential as a safe and highly effective treatment for depression, PTSD, mood disorders, and chronic pain.

 

Contact Ketamine Clinics of Los Angeles

If you or someone you love is seeking help for depression, PTSD, or another form of mood disorder, or coping with chronic pain, we encourage you to contact Dr. Steven L. Mandel at Ketamine Clinics of Los Angeles immediately to find out if IV Ketamine Infusion Therapy may offer a solution.

We encourage you to visit our website at https://www.ketamineclinics.com/ or contact us at 424-343-8889 to schedule an appointment.

For more information about Ketamine Infusion Therapy treatments for depression, bipolar, anxiety, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), fibromyalgia, pain syndromes and other conditions contact us at Ketamine Clinics of Los Angeles in Southern California (Orange County) by clicking here or calling  310-270-0625.

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