Learn more about Ketamine Infusion Therapy

Discover how ketamine infusion therapy can relieve various types of depression, suicidal thinking, post-traumatic stress disorder (PTSD), anxiety, obsessive-compulsive disorder (OCD), other mood disorders, and chronic pain conditions.

About Ketamine Infusion Therapy

Ketamine is an anesthetic that was approved by the FDA in 1970 and quickly became one of the most widely used anesthetics in the world. It has the ability to anesthetize patients quickly and safely with few side effects. Unlike many other anesthetics, ketamine does not depress patients’ breathing or circulatory systems, so it is commonly used on the battlefield and in environments without adequate monitoring equipment. Ketamine is also commonly used as a painkiller, especially for severe injuries and in crisis situations, due to its fast-acting analgesic effects.

“Ketamine is an Essential Medicine” -World Health Organization

Ketamine is one of only two anesthetics listed by the World Health Organization (WHO) as an “essential drug”. The WHO is a specialized agency of the United Nations concerned with international public health. Their essential drugs are “those drugs that satisfy the health care needs of the majority of the population; they should, therefore, be available at all times in adequate amounts and in appropriate dosage forms, at a price the community can afford.” WHO’s essential drugs are the basis for many countries’ national drug policies.

Is Ketamine Right For Me?


Benefits of Ketamine Infusion Therapy For Depression & Pain

For over 20 years, ketamine treatments have become an increasingly popular solution for difficult to treat conditions, including treatment-resistant depression, suicidal thinking, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), other mood disorders, Complex Regional Pain Syndrome (CRPS/RSD), and other pain conditions. Celebrated for producing high-quality relief that addresses these afflictions at the source, ketamine therapy has been called the biggest breakthrough treatment in 50 years.   

More than 100 clinical trials at leading medical institutions and universities have proven the efficacy of ketamine treatment for depression, anxiety disorder therapy, other mood disorders, and pain conditions. Most of these studies have singled out severe, treatment-resistant cases that have not responded to many other conventional treatment options and they still report a success rate of 70% or higher 

Ketamine for suicide prevention has also shown tremendous promise. Yale, Stanford, and New York universities, USC, UCLA, Cleveland Clinic, The National Institute of Mental Health, Massachusetts General Hospital, and Mt. Sinai are just a few of the leading institutions that have conducted research proving ketamine’s efficacy for the treatment of suicidality.

Multiple Infusions vs. Single Infusion

Much of the early research conducted on Ketamine Infusion Therapy was based on a single infusion, which proposes two problems. The first is that many patients don’t respond to treatment until after their second or third infusion, while some require a full series of six before experiencing significant relief from their symptoms. 

The second problem is the results are generally reported to last an average of 7-10 days with a single infusion. This caused many critics to say, “It works, but it doesn’t last.” Because of these findings, the team at KCLA pioneered a series of six infusions over 2-3 weeks, producing more pronounced and much longer-lasting ketamine benefits. Since we pioneered this approach, many research papers have been published on the multiple infusion protocol. (See our press and research page for details.) 

Although ketamine is also provided intramuscularly (IM), intranasally as a nasal spray, orally, and subcutaneously for mood disorders and chronic pain, KCLA focuses exclusively on administering ketamine intravenously. The reason for this is we are an evidence-based practice that believes in continuity of care and places patient comfort and safety first. Intravenous ketamine infusion therapy for depression, other mood disorders, and chronic pain is the only method of administration that has been clinically proven to be highly effective. We achieve an 83% success rate in our clinic through IV infusions of ketamine and the patient experience is significantly better than alternative routes of administration. Contact us today to learn more and schedule a free phone consultation.

Ketamine infusion treatment



Mother of PTSD and depression patient

I saw my son once again.

Although all the medical treatment Matt has received was valuable in some way, the only time in 16 years I saw the person who is my son once again quietly emerge, was after the ketamine infusions.

Allen C. 34 year old Male, Engineer

My successes have been phenomenal.

I have cut down on my Effexor to 75 Mg per day. I have eliminated lithium from my regiment and haven’t needed ambien for about month now to sleep. My klonopin I’ve reduced to once every other day. The infusions really helped my depression and chronic pain in my neck. My depression has never been better and I am cutting down on my other medications with great success. Thank you, thank you Dr. Mandel!

37 Year Old Woman, Registered Nurse

When I found Ketamine Clinics of Los Angeles,

When I found Ketamine Clinics of Los Angeles, and began to research the treatment, I felt my spirits lift. I felt hope. From the moment I called their office, I knew I was in good hands. As someone who works in healthcare, I couldn’t believe how kind and attentive Dr. Mandel and his entire staff were. I know they really care about me.

Keith W. 60 year old male, Lawyer

My doctor recommended that I try Ketamine

My doctor recommended that I try Ketamine at this time because he considers that there is now enough clinical information to make an informed decision about its effectiveness and side effects, and specifically recommended Dr. Mandel, who even with a glowing recommendation from someone for whom I have tremendous respect vastly exceeded all of my expectations.


Dr. Mandel has truly made my unlivable life, livable again.

Dr. Mandel has truly made my unlivable life, livable again. My ability to get out of bed early and or nearly right as I wake up has significantly improved. I’m able to keep up with my incredibly hectic schedule. My overall mood is high and lethargy is low. My social anxiety is at an all time low, and I haven’t had a panic attack since my first infusion.

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