Treatment-Resistant Unipolar Depression

People suffering from unipolar depression can become treatment-resistant — a situation where they do not respond to conventional treatments or therapies and cannot get their mood disorder under control. Ketamine therapy is proving to be especially effective for the treatment of mood disorders, including unipolar depression, bipolar depression, and similar disorders. We offer low-dose ketamine infusions to provide relief from symptoms of depression.

Understanding Unipolar Depression

Unlike bipolar depression, sufferers of unipolar depression only experience a depressed mood for a certain period. In most cases, a depressive episode lasts for at least two weeks and the sufferer experiences symptoms most of the day, or nearly every day, during the episode.

Symptoms of Unipolar Depression

Symptoms may include loss of interest or pleasure, irritability, an abnormal depressed mood, sleep disturbances, loss of energy, and thoughts of death or suicide. These symptoms are not related to a physical illness, side effects of medication, alcohol, or street drugs and it’s important to note there is no manic or hypomanic episode. The goal of treatment is to reduce or eliminate symptoms so the sufferer has a more stable mood.

Is Ketamine Right For Me?


Unipolar Depression Treatment Options

Antidepressant medications, sometimes administered at therapeutic doses, combined with psychotherapy is a common form of treatment for unipolar depression. However, antidepressants are not without their side effects and some can interfere with daily life because of their sedative effects. Common medications and treatment options for unipolar depression include:

  • Tricyclic antidepressant (TCAs), such as imipramine and nortriptyline, to improve mood
  • Selective Serotonin Reuptake Inhibitors (SSRIs), such as Prozac, Luvox, Paxil, or Zoloft to improve mood
  • Second generation antidepressants, such as Buproprion, Wellbutrin, Effexor, Desyrel, Serzone, and Remeron
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Psychotherapy for support, alone or with medication
  • As a last resort, Electroconvulsive Therapy (ECT), usually recommended for treating major depressive disorder

Ketamine Infusion Therapy for Unipolar Depression

Recent findings published in the Neural Regeneration Research journal reveal ketamine infusion therapy has lasting benefits for patient with depression and does not increase the risk of addiction. Ketamine Clinics of Los Angeles provides low-dose ketamine infusions for depression and most patients see relief within one to two days after their second infusion.

Patients undergoing ketamine therapy for unipolar depression do not need to worry about the side effects associated with antidepressants, SSRIs, and MAOIs. In many cases, depressive symptoms are lifted within a matter of weeks, reducing or eliminating dependence on prescription medications. Patients who have been unable to get relief from depressive symptoms with conventional therapies and treatments may be ideal candidates for ketamine infusion therapy.

Get Treatment for Unipolar Depression Today

If you or a loved one is suffering from unipolar depression, consider the benefits of ketamine infusion therapy to relieve symptoms. Complete a free Depression Assessment or contact Ketamine Clinics of Los Angeles to learn more about the benefits of ketamine therapy for mood disorders.



Mother of PTSD and depression patient

I saw my son once again.

Although all the medical treatment Matt has received was valuable in some way, the only time in 16 years I saw the person who is my son once again quietly emerge, was after the ketamine infusions.

Allen C. 34 year old Male, Engineer

My successes have been phenomenal.

I have cut down on my Effexor to 75 Mg per day. I have eliminated lithium from my regiment and haven’t needed ambien for about month now to sleep. My klonopin I’ve reduced to once every other day. The infusions really helped my depression and chronic pain in my neck. My depression has never been better and I am cutting down on my other medications with great success. Thank you, thank you Dr. Mandel!

37 Year Old Woman, Registered Nurse

When I found Ketamine Clinics of Los Angeles,

When I found Ketamine Clinics of Los Angeles, and began to research the treatment, I felt my spirits lift. I felt hope. From the moment I called their office, I knew I was in good hands. As someone who works in healthcare, I couldn’t believe how kind and attentive Dr. Mandel and his entire staff were. I know they really care about me.

Keith W. 60 year old male, Lawyer

My doctor recommended that I try Ketamine

My doctor recommended that I try Ketamine at this time because he considers that there is now enough clinical information to make an informed decision about its effectiveness and side effects, and specifically recommended Dr. Mandel, who even with a glowing recommendation from someone for whom I have tremendous respect vastly exceeded all of my expectations.


Dr. Mandel has truly made my unlivable life, livable again.

Dr. Mandel has truly made my unlivable life, livable again. My ability to get out of bed early and or nearly right as I wake up has significantly improved. I’m able to keep up with my incredibly hectic schedule. My overall mood is high and lethargy is low. My social anxiety is at an all time low, and I haven’t had a panic attack since my first infusion.